Pesquisa sobre:
FORKHEAD BOX PROTEIN O1
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DeCS
Descritor
Inglês
:
Forkhead Box Protein O1
Descritor
Espanhol
:
Proteína Forkhead Box O1
Descritor
Português
:
Proteína Forkhead Box O1
Sinônimos
Inglês
:
FOXO1 Protein
Forkhead in Rhabdomyosarcoma Protein
Categoria:
D12.776.260.950.249.250
D12.776.930.977.249.250
Definição
Inglês
:
A forkhead box transcription factor that is a major target of
INSULIN
signaling and regulator of metabolic
homeostasis
in response to
OXIDATIVE STRESS
. It binds to the
insulin
RESPONSE ELEMENT (IRE) and the related Daf-16
family
binding element (DBE). Its activity is suppressed by
insulin
and it also regulates
OSTEOBLAST
proliferation, controls bone mass, and skeletal regulation of
GLUCOSE
metabolism
. It promotes
GLUCONEOGENESIS
in
HEPATOCYTES
and regulates
gene expression
in
ADIPOSE TISSUE
. It is also an important
CELL DEATH
regulator. Chromosomal aberrations involving the FOXO1 gene occur in
RHABDOMYOSARCOMA.
Nota Histórica
Inglês
:
2017
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
56616
Identificador Único:
D000071161
Ocorrência na BVS
:
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